A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease
نویسندگان
چکیده
منابع مشابه
NOD2/CARD15 gene, Crohn’s Disease, mutation, Inflammatory bowel disease, Ulcerative colitis.
سابقه و هدف: ژن NOD2/CARD15 واقع در ناحیه کروموزومی(IBD1)16q12 به عنوان اولین ژن همراه با بیماریهای التهابی روده، به خصوص بیماری کرون مطرح شده است. بسیاری مطالعات همراهی متفاوتی از جهشهای این ژن با بیماریهای التهابی روده را در جمعیتهای مختلف گزارش کرده اند. در این مطالعه، فراوانی سه جهش شایع ژن CARD15 را در بیماران ایرانی مبتلا به بیماریهای التهابی روده، در مقایسه با افراد شاهد بررسی نموده ایم...
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ژورنال
عنوان ژورنال: Nature
سال: 2001
ISSN: 0028-0836,1476-4687
DOI: 10.1038/35079114